Effect of Plasmodium yoelli nigeriensis infection and chloroquine on the hepatic mixed function oxidase system of mice
Identifieur interne : 003303 ( Main/Exploration ); précédent : 003302; suivant : 003304Effect of Plasmodium yoelli nigeriensis infection and chloroquine on the hepatic mixed function oxidase system of mice
Auteurs : Nalini Saxena [Inde] ; Abha Saxena [Inde] ; Guru P. Dutta [Inde] ; Satyendra Ghatak [Inde] ; Vikash C. Pandey [Inde]Source :
- Molecular & Biochemical Parasitology [ 0166-6851 ] ; 1987.
English descriptors
- Teeft :
- Albino mice, Ancylostoma ceylanicum, Aniline hydroxylase, Berghei, Berghei infection, Biochem, Body weight, Central drug research institute, Chanan singh, Chloroquine, Cytochrome, Cytochrome hydroxylase, Different levels, Drug metabolising enzymes, Drug metabolism, Drug treatment, Experimental group, Experimental infection, Function oxidase system, Hepatic, Hepatic cytochrome, Hydroxylase, Liver microsomes, Malaria, Malaria infection, Metabolising, Mice liver, Microsomal, Microsomal enzymes, Moisture content, Mouse liver, Nigeriensis, Oxidase, Parasitaemia, Plasmodium, Plasmodium berghei, Plasmodium berghei infection, Plasmodium yoelii nigeriensis infection, Reductase, Separate observations, Total protein.
Abstract
Abstract: Plasmodium yoelli nigeriensis infection in albino mice significantly altered the hepatic microsomal mixed function oxidase system. Cytochrome P-450 (the terminal monooxygenase) and other monooxygenases, viz. aniline hydroxylase, aminopyrine-N-demethylase and benzo(a)pyrene hydroxylase were significantly lowered while microsomal heme showed 4-fold increase at 80% parasitaemia. Noticeable impairment in the other components like NADH:cytochrome b5 reductase, NADPH:cytochrome c reductase, cytochrome b5 and glucose-6-phosphatase was also observed. Oral treatment of normal and P. y. nigeriensis infected mice with chloroquine (64 mg per kg body weight for 4 days) caused lowering of mixed function oxidase activitied which however showed a recovering trend, a week after cessation of treatment.
Url:
DOI: 10.1016/0166-6851(87)90160-5
Affiliations:
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Pandey, Biochemistry Division, Central Drug Research Institute, Lucknow 226 001</wicri:regionArea><wicri:noRegion>Lucknow 226 001</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Biochemistry, Central Drug Research Institute, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Molecular & Biochemical Parasitology</title><title level="j" type="abbrev">MOLBIO</title><idno type="ISSN">0166-6851</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987">1987</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="283">283</biblScope><biblScope unit="page" to="287">287</biblScope></imprint><idno type="ISSN">0166-6851</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0166-6851</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Albino mice</term><term>Ancylostoma ceylanicum</term><term>Aniline hydroxylase</term><term>Berghei</term><term>Berghei infection</term><term>Biochem</term><term>Body weight</term><term>Central drug research institute</term><term>Chanan singh</term><term>Chloroquine</term><term>Cytochrome</term><term>Cytochrome hydroxylase</term><term>Different levels</term><term>Drug metabolising enzymes</term><term>Drug metabolism</term><term>Drug treatment</term><term>Experimental group</term><term>Experimental infection</term><term>Function oxidase system</term><term>Hepatic</term><term>Hepatic cytochrome</term><term>Hydroxylase</term><term>Liver microsomes</term><term>Malaria</term><term>Malaria infection</term><term>Metabolising</term><term>Mice liver</term><term>Microsomal</term><term>Microsomal enzymes</term><term>Moisture content</term><term>Mouse liver</term><term>Nigeriensis</term><term>Oxidase</term><term>Parasitaemia</term><term>Plasmodium</term><term>Plasmodium berghei</term><term>Plasmodium berghei infection</term><term>Plasmodium yoelii nigeriensis infection</term><term>Reductase</term><term>Separate observations</term><term>Total protein</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Plasmodium yoelli nigeriensis infection in albino mice significantly altered the hepatic microsomal mixed function oxidase system. Cytochrome P-450 (the terminal monooxygenase) and other monooxygenases, viz. aniline hydroxylase, aminopyrine-N-demethylase and benzo(a)pyrene hydroxylase were significantly lowered while microsomal heme showed 4-fold increase at 80% parasitaemia. Noticeable impairment in the other components like NADH:cytochrome b5 reductase, NADPH:cytochrome c reductase, cytochrome b5 and glucose-6-phosphatase was also observed. Oral treatment of normal and P. y. nigeriensis infected mice with chloroquine (64 mg per kg body weight for 4 days) caused lowering of mixed function oxidase activitied which however showed a recovering trend, a week after cessation of treatment.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Saxena, Nalini" sort="Saxena, Nalini" uniqKey="Saxena N" first="Nalini" last="Saxena">Nalini Saxena</name></noRegion><name sortKey="Dutta, Guru P" sort="Dutta, Guru P" uniqKey="Dutta G" first="Guru P." last="Dutta">Guru P. Dutta</name><name sortKey="Ghatak, Satyendra" sort="Ghatak, Satyendra" uniqKey="Ghatak S" first="Satyendra" last="Ghatak">Satyendra Ghatak</name><name sortKey="Pandey, Vikash C" sort="Pandey, Vikash C" uniqKey="Pandey V" first="Vikash C." last="Pandey">Vikash C. Pandey</name><name sortKey="Pandey, Vikash C" sort="Pandey, Vikash C" uniqKey="Pandey V" first="Vikash C." last="Pandey">Vikash C. Pandey</name><name sortKey="Saxena, Abha" sort="Saxena, Abha" uniqKey="Saxena A" first="Abha" last="Saxena">Abha Saxena</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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